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目的探讨乳腺癌组织中p53、C-erbB-2表达及临床意义。方法对免疫组织化学染色SP法检测240例乳腺癌组织石腊切片上p53、C-erbB-2的表达结果进行回顾性分析。结果p53和C-erbB-2阳性表达率分别为53.3%和63.3%;阳性产物主要位于细胞核中,p53和C-erbB-2的表达与肿瘤组织分级、淋巴结转移呈显著相关(P<0.05),与PR、ER无显著相关。结论p53和C-erbB-2与乳腺癌的发生发展密切相关,可作为判断肿瘤浸润转移、指导治疗和估计预后的参考指标。特别是p53的表达水平及淋巴结转移是判断乳腺癌预后的独立有效指标。
Objective To investigate the expression of p53 and C-erbB-2 in breast cancer and its clinical significance. Methods The expression of p53 and C-erbB-2 in paraffin section of 240 cases of breast cancer detected by immunohistochemical SP method was retrospectively analyzed. Results The positive rates of p53 and C-erbB-2 were 53.3% and 63.3% respectively. The positive products were mainly located in the nucleus. The expressions of p53 and C-erbB-2 were significantly correlated with tumor grade and lymph node metastasis (P <0.05) , No significant correlation with PR, ER. Conclusions The expression of p53 and C-erbB-2 is closely related to the occurrence and development of breast cancer, which can be used as a reference index to judge the invasion and metastasis of tumor, guiding the treatment and estimating the prognosis. In particular, p53 expression and lymph node metastasis is an independent prognostic indicator of breast cancer.