β－趋化因子受体５（ＣＣＲ５）是近年来新克隆的趋化因子受体超基因家族的一个重要成员之一，由于它的被发现才使人们认识到ＨＩＶ－１ 的感染除了Ｔ 细胞上的ＣＤ４＋ 外还有另一条通过巨噬细胞表面辅助受体ＣＣＲ５ 介导的传播途径。本文就近年来有关趋化因子受体基因家族的组成成员、结构与功能、不同人种的基因型、ＨＩＶ－１ 与细胞表面辅助受体ＣＣＲ５ 的结合，进入机理及阻断ＨＩＶ－１ 感染的可能途径作一详要的综述 β-Chemokine Receptor 5 (CCR5) is one of the important members of the newly cloned chemokine receptor supergene family in recent years. Because of its discovery, it has been recognized that HIV-1 infection except T cells On CD4 + there is another pathway mediated by CCR5 mediated by macrophage surface receptors. In this paper, in recent years, the composition of members of the chemokine receptor gene family, structure and function, different race genotypes, HIV-1 and cell surface receptor CCR5 binding, entry mechanism and the possibility of blocking HIV-1 infection Ways to make a detailed overview