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中耳胆脂瘤对颞骨的溶骨性破坏是其最重要的临床特征和病理生理学过程,但胆脂瘤骨质破坏的确切病因尚未清楚。胆脂瘤组织酸性环境与骨质脱矿物质有关,还为胶原酶破坏骨胶原提供前提条件。碳酸酐酶(carbonicanhydrase,CA)是一种含锌的金属酶,目前确定至少有7种同功酶〔1〕,CA参?
The osteolytic destruction of temporal bone by cholesteatoma is the most important clinical feature and pathophysiological process. However, the exact etiology of osteolysis of cholesteatoma remains unclear. Cholesteatoma tissue acidic environment and bone demineralization substances, collagen Collagenase also provide preconditions for the destruction of collagen. Carbonic anhydrase (CA) is a zinc-containing metalloenzyme, at least seven isozymes have been identified [1], CA parameters