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目的研究氯胺酮麻醉后对不同年龄组烧伤患者术后认知功能的影响。方法采用MMSE评分的方法,通过对临床245例患者的临床调查研究了氯胺酮麻醉对不同年龄组[A组(16～20岁)、B组(21～40岁)、C组(41～60岁)、D组(≥60岁)]烧伤患者认知功能的影响。结果术后第1天与其术前相比,A、B、C、D组的MMSE评分均下降(P<0.05);术后第7天与其术前相比,A、B、C组的MMSE评分没有明显变化(P>0.05),而D组的MMSE评分下降(P<0.05)。患者认知功能障碍发生率比较,A、B、C、D四组术后第1天发生率均较术后第7天为高(P<0.05);A、B、C、D四组两两比较,D组术后第1天、第7天发生率均较A、B、C组为高(P<0.05),A、B、C组之间差异无统计学意义(P>0.05)。结论氯胺酮麻醉后对不同年龄组的认知功能影响不同,认知功能障碍的发生可能与患者的年龄有关。
Objective To study the effect of ketamine anesthesia on postoperative cognitive function in burn patients of different age groups. Methods The MMSE score method was used to investigate the effects of ketamine anesthesia on different age groups (group A (16-20), group B (21-40), group C (41-60) ), Group D (≥60 years old)] on the cognitive function of burn patients. Results On the first day after operation, the MMSE scores of A, B, C and D groups decreased compared with those before operation (P <0.05). On the 7th day after operation, the MMSE scores of A, B and C groups The score did not change significantly (P> 0.05), while the MMSE score of group D decreased (P <0.05). The incidence of cognitive dysfunction in patients with A, B, C, D four groups on the first postoperative day than postoperative day 7 was higher (P <0.05); A, B, C, D four groups In the two groups, the incidence of postoperative day 1 and day 7 in group D was significantly higher than that in groups A, B and C (P <0.05), but there was no significant difference between groups A, B and C (P> 0.05) . Conclusions Ketamine has different effects on cognitive function in different age groups after anesthesia. The incidence of cognitive impairment may be related to the patient’s age.