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目的:探讨氯沙坦联合利尿剂治疗高血压的临床效果。方法:选择中山市沙溪隆都医院2013年6月至2015年6月收治的中老年高血压患者120例,随机分为观察组和对照组,各60例,对照组单用氯沙坦,观察组在氯沙坦的基础上,加用利尿剂进行治疗,比较两组患者降压效果和不良反应发生率。结果:(1)与对照组70.00%对比,观察组临床有效率96.67%明显更高,差异具有统计学意义(P<0.05)。(2)与对照组5.00%对比,观察组不良反应发生率8.33%略高,差异无统计学意义(P>0.05)。(3)与对照组对比,观察组血尿素氮(BUN)、血肌酐(Scr)、钾离子(K~+),差异无统计学意义(P>0.05);收缩压(SBP)、舒张压(DBP)明显更低,差异具有统计学意义(P<0.05)。与治疗前对比,两组患者治疗后SBP、DBP分别低于治疗前,差异具有统计学意义(P<0.05)。结论:氯沙坦联合利尿剂治疗高血压的临床效果显著,安全性良好。
Objective: To investigate the clinical effect of losartan combined with diuretic in the treatment of hypertension. Methods: A total of 120 middle-aged and elderly patients with hypertension were selected from Shaxi Longdu Hospital of Zhongshan City from June 2013 to June 2015. They were randomly divided into observation group and control group, 60 cases in each group. Losartan, The observation group was treated with losartan on the basis of losartan, and the antihypertensive efficacy and the incidence of adverse reactions were compared between the two groups. Results: (1) Compared with 70.00% in the control group, the clinical effective rate in the observation group was significantly higher (96.67%), the difference was statistically significant (P <0.05). (2) Compared with the control group of 5.00%, the incidence of adverse reactions in the observation group was slightly higher than that of the control group (8.33%), with no significant difference (P> 0.05). (3) Compared with the control group, the blood urea nitrogen (BUN), serum creatinine (Scr), potassium ion (K ~ +) in the observation group had no statistical significance (P> 0.05); systolic blood pressure (SBP) (DBP) was significantly lower, the difference was statistically significant (P <0.05). Compared with pre-treatment, SBP and DBP in the two groups after treatment were lower than before treatment, the difference was statistically significant (P <0.05). Conclusion: Losartan combined with diuretic in the treatment of hypertension has obvious clinical effect and good safety.