制备单克隆抗体的免疫原——杂交瘤细胞之亲代细胞系,目前大多取自BALB/c系小鼠。另据Brader等报道,应用BALA/c×Swiss Webster/HPB杂交一代小鼠制备单克隆抗体,取得了腹水量大、连续收获时间长的良好结果。且雄鼠得率不亚于雌鼠。我们于1986年6月应用BALB/c系(?)与SSB系(?)杂交的F_1小鼠制备单克隆抗体,取得了一定收获, The preparation of monoclonal antibody immunogen - hybridoma cell line of the parent strain, most of the time taken from BALB / c mice. According to Brader et al., Monoclonal antibodies were also prepared from the BALA / c × Swiss Webster / HPB hybrid generation mice and achieved good results with large amounts of ascites and long continuous harvest time. Male rats and no less than the rate of female rats. In June 1986, monoclonal antibodies were obtained from F_1 mice which hybridized with BALB / c line (?) And SSB line (?), And obtained some harvest,