由于寄生虫病而引起的宿主形态功能的改变可能影响药物动力学。作者应用本系列研究中已建立的野生鼠实验丝虫病模型,观察感染鼠和非感染鼠口服海群生(DEC)后血浆及腹腔液中的药物浓度,以研究丝虫寄生对DEC 动力学过程的影响。该模型的宿主为中南美棘鼠(Proechimys oris),寄生虫为棘唇丝虫(Dipeta-lonema dessetae),以埃及伊蚊为媒介。模型对常用的抗丝虫药敏感。感染组和对照组各5只雄鼠,一次口服DEC 盐基100mg/kg,收集48h 内的尿、粪,并定时取血样。为测定腹腔液中的DEC 浓度,先以6ml 等渗溶液于给药前45min 注入腹腔,给药后自腹腔取样0.5ml。用气相层析法定量测定各样品中的DEC 含量。实验数据经权重后,用最小二乘法线性回归分析处理。动力学参数按通常方法计算。结果表明,48h 内对照组尿、粪中的DEC 排出量 Changes in host morphological function due to parasites may affect pharmacokinetics. The authors used the established model of wild-type experimental filariasis in this series of studies to observe the plasma and peritoneal fluid concentrations of infected and non-infected mice after oral administration of decoction (DEC) to study the effects of filarial parasitism on DEC kinetics Impact. The model host was Echinacea oris, the parasite was Dipeta-lonema dessetae, and the vector was Aedes aegypti. The model is sensitive to commonly used antifungals. Infected and control groups of 5 male rats, one oral DEC salt base 100mg / kg, collected within 48h of urine, feces, and blood samples taken regularly. To determine the concentration of DEC in peritoneal fluid, 6 ml of isotonic solution was injected into the abdominal cavity 45 min before administration and 0.5 ml from the abdominal cavity after administration. The content of DEC in each sample was quantitatively determined by gas chromatography. After the experimental data by weight, using least squares linear regression analysis and processing. Kinetic parameters are calculated as usual. The results showed that the control group within 48h urine, excretion of DEC emissions