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为探讨自体外周血造血干细胞移植（Ａｕｔｏ－ＰＢＳＣＴ）预处理的远期毒副作用，对８例Ａｕｔｏ－ＰＢＳＣＴ术后生存４～８年的恶性肿瘤患儿进行了随访。结果，８例患儿生长发育、神经精神发育、肾上腺皮质功能及免疫功能均正常。７例患儿甲状腺功能正常，１例发生代偿性甲状腺功能低下。５例进入青春期的患儿中４例性腺功能基本正常，１例男性性腺发育迟缓（伴有继发性血色病）。发现轻度白内障５例。５例丙型肝炎抗体阳性，其中４例肝功能异常，１例患乙型肝炎。提示，恰当的预处理方案对患儿远期生长发育、神经精神系统、内分泌、免疫系统无影响或影响较小，但轻度白内障发生率高，乙型肝炎、丙型肝炎在其治疗过程中的预防应引起重视。
To investigate the long-term toxicities and side effects of Auto-PBSCT preconditioning, 8 children with malignant tumors who survived 4 to 8 years after Auto-PBSCT were followed up. Results, 8 cases of children with growth and development, neuropsychiatric development, adrenal function and immune function are normal. Thyroid function was normal in 7 cases and compensatory hypothyroidism in 1 case. Of the 5 children who entered adolescence, 4 had normal gonadal function and 1 had gonadal retardation (with secondary hemochromatosis). 5 cases of mild cataract were found. Five cases of hepatitis C antibody positive, including four cases of liver dysfunction, one case of hepatitis B. Tip, the appropriate pretreatment program on children with long-term growth and development, neuropsychiatric system, endocrine, immune system had little or no effect, but the incidence of mild cataract, hepatitis B, hepatitis C in the course of its treatment Prevention should pay attention.