为研究脂质过氧化反应在脊髓损伤中的作用,检测了79例脊髓灰质炎患儿血清丙二醛(MDA)。结果血MDA 在急性期显著升高,3周后渐降至正常。同时还观察到维生素E、超氧化物歧化酶、过氧化氢酶和二甲基亚砜等抗氧化剂能降低大鼠脊髓损伤组织和血清的MDA 水平。提示脊灰炎患儿和机械性脊髓损伤大鼠都存在脂质过氧化反应亢进。抗氧化剂可减轻实验大鼠的脂质过氧化,并提出脊灰炎早期抗氧化剂治疗的设想。 To study the role of lipid peroxidation in spinal cord injury, serum malondialdehyde (MDA) was detected in 79 children with polio. Results Blood MDA increased significantly during the acute phase and gradually returned to normal after 3 weeks. At the same time, antioxidants such as vitamin E, superoxide dismutase, catalase, and dimethyl sulfoxide were also observed to reduce MDA levels in rat spinal cord injured tissues and serum. It suggests that hyperlipidemia is present in both children with polio and mechanical spinal cord injury. Antioxidants can reduce lipid peroxidation in experimental rats and suggest the idea of ​​early anti-oxidant treatment for polio.