大约30年前D·rner提出成人疾病危险率和机体功能在关键的发育早期中受激素和代谢产物程序性影响。的确,饮食因素可调节妊娠期和哺乳期女性及其子女的器官生长和机能发育,并且可长期程序性地影响成年期的健康、疾病和发病率、神经功能和行为以及生活质量。以往诸多关于人类营养程序性的研究均未表明其与饮食直接相关,也未确定二者是否存在因果关系进而妊娠女性和婴儿明确而适宜的饮食建议。同样,在关键的产前和产后也存在着悬而未决的问题,这一时期的营养水平对后期健康产生程序性影响。因此,需要采用与人群随机对照试验、预期观察研究和动物实验相结合的新方法来研究成人健康的早期程序化。考虑到对公众健康、政策和产品开发的长远效应,早期营养程序化研究为主要投资方向是可行的。 About thirty years ago, D · rner proposed risk factors for adult disease and body function were hormonally and metabolically affected by programmed events during the crucial early stages of development. Indeed, dietary factors regulate organ growth and function development in both gestational and lactating women and their children and can affect adulthood health, disease and morbidity, neurological function and behavior, and quality of life for long periods of time. In the past, many studies on the procedural aspects of human nutrition did not indicate that they were directly related to diet, nor did they determine whether there was a causal relationship between the two and that women’s and babies’ explicit and appropriate dietary recommendations. Similarly, there are unresolved issues at key prenatal and postnatal periods, where nutrition levels have a procedural impact on later health. Therefore, there is a need for new approaches to studying adult health in early programming using a combination of randomized controlled trials with humans, prospective observational studies and animal experiments. Taking into account the long-term effects on public health, policy and product development, early nutrition programmatic research is likely to be the main investment direction.