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本文考察了大鼠按8mg/kg静注鹤草酚静脉乳后,心、肝、脾、肺、肾、脑、脊髓、肌肉和睾丸中药物浓度的经时变化。非房室模型分析结果表明:肝脏摄取量最高,其它依次为脾、脑、心、肾、肺、睾丸、脊髓和肌肉。大鼠静注一负荷剂量4.4mg/kg后,再以1.112mg/kg·h静滴至稳态;在稳态测定鹤草酚在血浆及组织中的浓度,由此计算鹤草酚组织-血浆表观分配系数。由组织-血浆表观分配系数计算得到的稳态分布容积与鹤草酚静脉乳药物动力学研究中非房室模型处理的结果基本一致。
In this study, the concentration changes of drugs in the heart, liver, spleen, lung, kidney, brain, spinal cord, muscle, and testicles were observed after rats were fed with 8 mg/kg intravenous agrovenol intravenous milk. Non-compartmental model analysis showed that the liver intake was highest, followed by spleen, brain, heart, kidney, lung, testis, spinal cord, and muscle. The rats were intravenously injected with a loading dose of 4.4 mg/kg, and then intravenously dropped to a steady state at 1.112 mg/kg.h; the concentration of agromycin in plasma and tissues was determined at steady state, and the agrimonol tissue was calculated by Plasma apparent partition coefficient. The steady-state volume of volume calculated from the apparent tissue-to-plasma partition coefficient was basically the same as that of non-compartmental models in pharmacokinetics studies of agrovenol intravenous milk.