论文部分内容阅读
目的:探讨血管紧张素转换酶(ACE)基因插入(I)/缺失(D)多态性与脑血管病(CVD)的关系。方法:采用聚合酶链反应技术(PCR)检测19Z例卒中患者、95例高血压病人和124例正常人的ACE基因多态性。结果:CVD组ACE基因D等位基因频率为0.58,明显高于高血压对照组(P＜0.02)和正常对照组(P＜0.01),DD基因型频率明显高于正常对照组(P＜0.05)。腔隙性梗死(LACI)组的DD基因型显著高于对照组(P＜0.05)。多元回归分析发现ACE*DD基因型与卒中无明显相关性(P＜0.08),而与LACI存在明显相关性(P=0.048)。结论:ACE基因缺失多态性在LACI的形成中可能产生重要作用。
Objective: To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion (I) / deletion (D) polymorphism and cerebrovascular disease (CVD). Methods: Polymerase chain reaction (PCR) was used to detect ACE gene polymorphism in 19 Z stroke patients, 95 hypertensive patients and 124 healthy controls. Results: The D allele frequency of ACE gene in CVD group was 0.58, significantly higher than that in hypertension control group (P <0.02) and normal control group (P <0.01). The frequency of DD genotype in CVD group was significantly higher than that in control group (P <0.05) ). The DD genotype in lacunar infarction (LACI) group was significantly higher than that in control group (P <0.05). Multivariate regression analysis found no significant association between ACE * DD genotype and stroke (P <0.08), but significant correlation with LACI (P = 0.048). Conclusion: ACE gene deletion polymorphism may play an important role in the formation of LACI.