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[目的]合成杂多酸甘氨酸超分子化合物,在进行表征的基础上探讨其抑菌活性。[方法]以Keggin结构杂多酸作为母体,将甘氨酸作为外界阳离子引入杂多化合物当中,合成了杂多酸氨基酸超分子化合物,同时研究其对金黄色葡萄球菌和大肠杆菌的抑制作用。[结果]采用液相和固相的方法成功合成杂多酸超分子化合物(HGly)4FeW11Cr。该超分子化合物对金黄色葡萄球菌和大肠杆菌具有一定的抑制作用,其中对大肠杆菌的抑制效果明显高于金黄色葡萄球菌。[结论]该研究为拓宽多酸化学的应用和开发新型抑菌剂提供依据。
[Objective] The research aimed to study the antibacterial activity of heteropolyacid-glycine supramolecular compounds on the basis of characterization. [Method] With the heteropolyacid of Keggin structure as the precursor, glycine was introduced into heteropoly compounds as external cations to synthesize the heteropoly compounds of heteropoly acid amino acids and to study its inhibitory effect on Staphylococcus aureus and Escherichia coli. [Result] The heteropoly acid heteropoly compound (HGly) 4FeW11Cr was successfully synthesized by liquid and solid phase methods. The supramolecular compound has a certain inhibitory effect on Staphylococcus aureus and Escherichia coli, and the inhibitory effect on Escherichia coli is obviously higher than that of Staphylococcus aureus. [Conclusion] The research provided the basis for broadening the application of polyacid chemistry and developing new antibacterial agents.