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本文报告人体一次静脉输注硫酸葡聚糖分别为15、20和25mg/kg,对人体外周血造血干细胞CFU-GM和单个核细胞(MNC)具有良好的动员作用,并有随给药剂量增大而外周血干细胞增加的趋势。静脉输注后3h,细胞数达高峰。输注后,除25mg/kg凝血系统在24h未能恢复正常外,余肝、肾和免疫功能等未见明显改变。
This article reports that human intravenous infusion of dextran sulfate at 15, 20 and 25 mg / kg, respectively, has good mobilization on human peripheral blood hematopoietic stem cells CFU-GM and mononuclear cells (MNC) Large and peripheral blood stem cells increased trend. 3h after intravenous infusion, the number of cells reached a peak. After infusion, except 25mg / kg coagulation system failed to return to normal in 24h, the liver, kidney and immune function had no significant changes.