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目的探讨血清胱抑素C(Cys-C)、β_2-微球蛋白(β_2-MG)和尿碱性磷酸酶(U-ALP)在糖尿病肾病中的诊断价值。方法将528例糖尿病患者分成3个组即肾功能无损伤组、肾功能轻度损伤组和肾功能重度损伤组,与对照组85例健康体检者分别比较血生化指标及尿生化指标检测结果,并进行统计学分析。结果糖尿病患者肾功能轻度损伤组和肾功能重度损伤组血清Cys-C、β_2-MG和U-ALP检测结果均高于肾功能无损伤组和对照组,差异有统计学意义(P<0.05);糖尿病患者肾功能无损伤组检测结果与对照组比较,差异无统计学意义(P>0.05);Cys-C、β_2-MG和U-ALP联合检测阳性检出率高于单个项目阳性检出率,差异有统计学意义(P<0.05)。结论血清Cys-C、β_2-MG和U-ALP可用于糖尿病肾病的临床诊断,联合检测血清Cys-C、β_2-MG和U-ALP可以提高阳性检出率。
Objective To investigate the diagnostic value of serum Cystatin C, β_2-MG and U-ALP in diabetic nephropathy. Methods 528 cases of diabetic patients were divided into three groups: renal function non-injury group, mild renal injury group and severe renal injury group, compared with 85 healthy controls in the control group, blood biochemistry indexes and urine biochemical indexes were respectively tested, And statistical analysis. Results The serum levels of Cys-C, β 2-MG and U-ALP in mild renal injury group and severe renal injury group were significantly higher than those in non-injury renal group and control group (P <0.05 (P> 0.05). The positive detection rate of Cys-C, β 2-MG and U-ALP was higher than that of single item positive test Rate of output, the difference was statistically significant (P <0.05). Conclusion Serum Cys-C, β 2-MG and U-ALP can be used in the clinical diagnosis of diabetic nephropathy. Combined detection of serum Cys-C, β 2-MG and U-ALP can increase the positive detection rate.