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测定４５例乳腺癌雌激素受体（ＥＲ）与细胞核ＤＮＡ含量．结果：ＥＲ阴性者２７例，平均ＤＮＡ含量４５．１１；ＥＲ阳性１８例，ＤＮＡ含量２９．７６．组织学分化程度Ⅰ、Ⅱ、Ⅲ级者ＥＲ阳性率分别为９／１５、５／１４和４／１６；平均ＤＮＡ含量分别为２５．２１、３５．６４和４６．３３．按临床分期Ⅰ、Ⅱ、Ⅲ期ＥＲ阳性分别为１０／１２、８／１７和８／１６；平均ＤＮＡ含量分别为３５．４２、３６；０７和３７．１９．不同组织学类型的ＥＲ阳性率和ＤＮＡ含量均无显著差别．提示：乳腺癌组织学分化程度与ＤＮＡ含量和ＥＲ状态明显相关．联合ＤＮＡ含量和ＥＲ测定能更准确了解乳腺癌的生物学特性，对判断预后和设计个体化辅助治疗方案可提供更可靠的依据．
The content of estrogen receptor (ER) and nuclear DNA in 45 cases of breast cancer were measured. Results: 27 cases were negative for ER, the average DNA content was 45.11; 18 cases were ER positive, DNA content was 29.76. The ER positive rates of histological grade I, II and III were 9/15, 5/14 and 4/16, respectively; the average DNA content was 25.21, 35.64 and 46.33, respectively. According to the clinical stage I, II, and III stages, the positive rates of ER were 10/12, 8/17, and 8/16, respectively; the average DNA contents were 35.42, 36, 07, and 37.19, respectively. There was no significant difference between the ER positive rate and DNA content in different histological types. 5. Tip: The degree of histological differentiation of breast cancer is significantly related to DNA content and ER status. Combined DNA content and ER determination can more accurately understand the biological characteristics of breast cancer and provide a more reliable basis for judging the prognosis and designing individualized adjuvant treatment programs.