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目的：研究全反式维甲酸（ＲＡ）对克隆化人肺癌高转移细胞亚系（ＰＧＣＬ３）恶性表型的影响。方法：在体外用５μｍｏｌ／Ｌ和１０μｍｏｌ／ＬＲＡ处理ＰＧＣＬ３细胞５ｄ后，观察其对肿瘤生长、粘附、运动、侵袭能力和裸鼠体内实验性转移的影响。结果：上述肿瘤恶性表型指标均受到不同程度的抑制，其抑制作用在ＲＡ高浓度组更加明显。结论：ＲＡ可抑制高转移癌系的恶性表型，为ＲＡ治疗恶性肿瘤，特别是转移性恶性肿瘤提供了实验依据。
OBJECTIVE: To study the effect of all-trans retinoic acid (RA) on the malignant phenotype of human lung cancer high metastatic cell subsets (PGCL3). METHODS: PGCL3 cells were treated with 5 μmol/L and 10 μmol/LRA in vitro for 5 days, and their effects on tumor growth, adhesion, movement, invasion and experimental metastasis in nude mice were observed. Results: The malignant phenotypes of these tumors were all inhibited to varying degrees, and their inhibitory effects were more pronounced in the high concentration group of RA. Conclusion: RA can inhibit the malignant phenotypes of highly metastatic cancers and provide experimental basis for RA treatment of malignant tumors, especially metastatic malignant tumors.