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目的:探讨ApoB基因多态性与新疆维吾尔族胆结石之间的关系。方法:采用前瞻性病例-对照研究方法,自2010年3月至2013年6月,收集在我院接受手术治疗的胆结石组:维吾尔族79例;正常对照组为年龄和性别与胆结石组相匹配的健康志愿者(同期在我院体检中心接受健康体检者):维吾尔族53例。采用SNa Pshot SNP分型技术进行Apo B基因分型,分析基因型分布在胆结石组和健康组间的差异。结果:Apo B基因等位基因频率和基因型频率在新疆维吾尔族胆结石组和对照组间无显著性差异(P>0.05)。结论:Apo B基因多态性与新疆维吾尔族胆结石不相关。但需要进一步增加样本含量及多中心研究来进一步证实。
Objective: To investigate the relationship between ApoB gene polymorphism and Uygur gallstones in Xinjiang. Methods: A prospective case-control study was conducted. From March 2010 to June 2013, 79 cases of Uigur Gallstone were collected for surgical treatment in our hospital. The normal control group was age and sex and gallstones group Matched healthy volunteers (over the same period in our hospital physical examination center to accept the health examination): Uighur 53 cases. Apo B genotyping was performed using the SNa Pshot SNP typing technique to analyze the differences in genotype distribution between the gallstone group and the healthy group. Results: There was no significant difference in allele frequency and genotype frequency of Apo B gene between Xinjiang Uigur nationality gallstone group and control group (P> 0.05). Conclusion: Apo B gene polymorphism is not related to Uygur gallstones in Xinjiang. However, a further increase in sample size and multicenter studies are needed to confirm this.