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目的:对静脉注射后大鼠体内川芎嗪药动学特征进行研究。方法:流动相为甲醇-0.05 mol/L醋酸-醋酸钠的水溶液(50∶50,V/V),流速为1.0 mL/min,紫外检测波长为280 nm。结果:川芎嗪静脉注射后体内血药浓度-时间过程符合二房室药动学模型,药物分布与消除半衰期分别为49.36 min与91.85 min,平均滞留时间MRT0～∞为141.61 min,AUC0～∞为7521.70μg·min/mL。结论:盐酸川芎嗪静脉注射后,在大鼠体内的药动学符合二房室模型,分布和消除均较快。
Objective: To study the pharmacokinetics of ligustrazine in rats after intravenous injection. Methods: The mobile phase consisted of methanol-0.05 mol / L acetic acid-sodium acetate (50:50, V / V) at a flow rate of 1.0 mL / min. The UV detection wavelength was 280 nm. Results: The plasma concentration-time course of Ligustrazine injection was in accordance with two-compartment pharmacokinetic model. The drug distribution and elimination half-life were 49.36 min and 91.85 min, respectively. The average retention time MRT0 ~ ∞ was 141.61 min and AUC0 ~ ∞ was 7521.70 μg · min / mL. Conclusion: After intravenous injection of ligustrazine hydrochloride, the pharmacokinetics in rats is in accordance with the two-compartment model, and the distribution and elimination are quicker.