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６氟７（４甲基１哌嗪基）８氨基４氧代１，４二氢喹啉３羧酸乙酯（５Ａ）和脂肪酸在ＰＰＡ中缩合，得２烃基６氧代８氟９（４甲基１哌嗪基）６Ｈ咪唑并（４，５，１ｉｊ）喹啉５羧酸（２Ａｂ～２Ａｅ），６氟７含氮杂环８氨基４氧代１，４二氢３喹啉羧酸（９Ａ～９Ｄ）与各种酸在ＰＰＡ中缩合或与原甲酸三乙酯缩合或经重氮化反应，可分别得到其它目的物２Ａｆ～２Ａｈ，２Ｂｃ，２Ｃｃ，２Ａａ～２Ｄａ，２Ｂｉ和２Ｃｉ。体外抗菌筛选证明仅化合物２Ａｂ和２Ａｃ具有中等程度的抗菌作用。
6 fluorine 7 (4 methyl 1 piperazinyl) 8 8 amino 4 oxygen 1, 4 dihydroquinoline 3 carboxylate (5A) and fatty acids in the PPA In condensation, were 2 hydrocarbon 6 oxo 8 fluorine 9 (4 methyl 1 piperazinyl) 6H imidazole and (4,5,1 j) quinoline 5 Carboxylic acid (2Ab ~ 2Ae), 6 fluorine 7 nitrogen-containing heterocyclic 8 8 amino 4 oxygen 1, 4 2 3 quinoline carboxylic acid (9A ~ 9D) and various acids The other targets 2Af to 2Ah, 2Bc, 2Cc, 2Aa to 2Da, 2Bi and 2Ci are respectively obtained by condensation in PPA or condensation with triethyl orthoformate or diazotization. In vitro antibacterial screening demonstrated that only compounds 2Ab and 2Ac had a moderate degree of antibacterial activity.