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一、离体兎心在正常乐氏液、正常乐氏液加酒石酸锑钠或低钾乐氏液灌注时,肾上腺素并不导致心室颤动。但在低钾乐氏液加酒石酸锑钠灌注时,则肾上腺素可使受试心脏全部发生心室颤动,即使用更小量的肾上腺素亦可产生。二、离体兎心灌注液中加酒石酸锑钠后,流出液的钾浓度显著提高,表示心肌钾离子外流增加。三、大白鼠连续注射酒石酸锑钾数天后,大量的肾上腺素即可导致心室颤动。四、实验结果除进一步证明锑剂有促使肾上腺素致颤作用外,并指出此种作用的机制和心肌钾离子外流损失有关。本文中对于锑剂导致心室颤动的可能机制亦加讨论。
First, the excitement of the heart in normal Le’s solution, normal Le’s solution plus antimony tartrate sodium or low potassium Le’s perfusion, adrenaline does not lead to ventricular fibrillation. However, in the low-potassium Le’s solution plus anti-sodium tartrate perfusion, then the epinephrine can make the heart all the ventricular fibrillation, even with a smaller amount of epinephrine can be produced. Second, in vitro 兎 heart perfusion solution with antimony tartrate sodium, the effluent potassium concentration was significantly increased, indicating an increase in myocardial potassium efflux. Third, the rats injected with antimony potassium tartrate for several days, a large number of epinephrine can lead to ventricular fibrillation. Fourth, the experimental results In addition to further evidence that antimony agent to promote adrenergic fibrillation, and pointed out that this mechanism of action and myocardial potassium efflux loss. In this article, the possible mechanism of antimony agent leading to ventricular fibrillation is also discussed.