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目的考察西咪替丁与甲硝唑、奥硝唑、阿昔洛韦、更昔洛韦、阿糖腺苷在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法在(25±2)℃条件下,于0、2、4、6 h取样观察配伍液的外观、p H值以及含量的变化。结果配伍液静置6 h后,其外观、p H、含量及紫外吸收峰的峰形、最大吸收波长均无明显变化。结论西咪替丁与上述抗厌氧菌及抗病毒药物在室温放置6小时后配伍液相对稳定,无明显物理性配伍禁忌。
Objective To investigate the compatibility of cimetidine with metronidazole, ornidazole, aciclovir, ganciclovir and vidarabine in 0.9% sodium chloride injection and 5% glucose injection. Methods The appearance, p H value and content of the mixed solution were observed at 0, 2, 4 and 6 h at (25 ± 2) ℃. Results After standing for 6 h, the appearance, p H, content and the peak shape and the maximum absorption wavelength of UV absorption peak did not change obviously. Conclusion Cimetidine and anti-anaerobic bacteria and antiviral drugs at room temperature for 6 hours after the compatibility was relatively stable, no significant physical incompatibility.