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第三代头孢菌素 LMOX(latamoxef sodium,拉塔莫含,羟羧氧乙酰胺菌素)在日本大阪医科大学妇产科教研室用于预防术后感染。本品是头孢菌素结构式中 S 被 O 置换,既具有头霉素的结构,又有不同于以往头孢菌素或头霉素的化学构造。故对 G~+菌和 G~-菌以及厌气菌均有广谱抗菌作用。因为对 G~-菌、厌气菌产生的β-青霉素酶(β-Lactamase)稳定,所以呈强效杀菌作用。此外,其一般毒性与头孢菌素相同或减少。LMOX 适用于妇科宫出感染、子宫附件炎、子宫旁结缔组织炎、盆腔炎等。现将 LMOX 在妇科生殖器官组织及血中药物浓度
Third-generation cephalosporin LMOX (latamoxef sodium, latamoxone, hydroxycarboxamycin) in Osaka Medical University Obstetrics and Gynecology Department for the prevention of postoperative infection. This product is cephalosporin structural formula S replaced by O, both with the structure of cephalosporins, there are different from the previous cephalosporin or cephamycin chemical structure. Therefore, G ~ + bacteria and G ~ - bacteria and anaerobic bacteria have broad-spectrum antibacterial effect. Because of G ~ - bacteria, anaerobic bacteria produce β-penicillinase (β-Lactamase) stable, so it was a potent bactericidal effect. In addition, its general toxicity and cephalosporins the same or reduced. LMOX for gynecological infection, uterine annex inflammation, para-uterine connective tissue inflammation, pelvic inflammatory disease and so on. Now LMOX in gynecological reproductive organs and blood drug concentrations