心力衰竭(CHF)是心血管疾病的共同结局,表现为神经体液的过度激活和进行性心室扩张。尽管神经激素抑制剂已广泛应用,但CHF的发病率和死亡率仍然很高。目前在动物和人体研究中发现氧自由基在CHF的发生发展中起重要作用。抗氧化剂在CHF早期使用有助于患者心功能的维持。普罗布考(Probucol)是一种脂溶性抗氧剂,已被证实可以保护实验性心肌梗死动物心功能,抑制氧自由基对心肌的损害。本研究拟探讨该药物对CHF小鼠心功能的维持和心室重塑的干预。 Heart failure (CHF) is a common outcome of cardiovascular disease characterized by over activation of neurohumoral fluid and progressive ventricular dilatation. Although neurohormonal inhibitors are widely used, the morbidity and mortality of CHF are still high. Currently in animal and human studies found that oxygen free radicals play an important role in the occurrence and development of CHF. The use of antioxidants early in CHF helps to maintain the patient’s cardiac function. Probucol, a fat-soluble antioxidant, has been shown to protect cardiac function in experimental myocardial infarction and to suppress myocardial damage by oxygen free radicals. This study was to investigate the intervention of the drug on the maintenance of cardiac function and ventricular remodeling in CHF mice.