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银纳米团簇因其独特的与尺寸相关的光、电、磁和催化性能,引起了相关研究人员的高度关注,我们团队一直专注于研究用基于DNA保护的银纳米团簇监测DNA、Hg2+和巯基化合物。发现发生在DNA/银纳米复合物与G-四链体/血红素之间光诱导电子转移(PET),伴随着DNA/银纳米荧光减弱。这一新的PET系统使目标生物分子,如DNA和敏感性高的ATP获得特异性和多样性的检测。首次提出一种以DNA单体作为支架的高产率银纳米簇的合成方法。在这项研究中,采用密度泛函计算理论解释了DNA保护的银纳米团簇的形成机理以及为什么富胞嘧啶DNA是荧光银纳米簇的良好支架。研究结果对DNA保护荧光银纳米簇进一步实验和理论研究提供了基本指导思想,最终可能有助于程序化合成具有光致发光性能的DNA稳定银纳米团簇。
Silver nanoclusters have attracted the attention of researchers due to their unique size-dependent optical, electrical, magnetic and catalytic properties. Our team has been focusing on the research of monitoring DNA, Hg2 + and Ag2 + by DNA-protected silver nanoclusters Mercapto compound. Photoinduced electron transfer (PET) between DNA / silver nanocomplex and G-quadruplex / heme was found to occur with DNA / silver nanofluorescence being attenuated. The new PET system enables the detection of specific and diverse biomolecules of interest, such as DNA and sensitive ATP. For the first time, a method of synthesizing high-yield silver nanoclusters using DNA monomer as a scaffold was proposed. In this study, the density-functional theory was used to explain the formation mechanism of DNA-protected silver nanoclusters and why cytosine DNA is a good scaffold for fluorescent silver nanoclusters. The results provide basic guidelines for further experimental and theoretical studies on the protection of fluorescent silver nanoclusters by DNA, which may ultimately help to synthesize DNA stable silver nanoclusters with photoluminescence properties.