论文部分内容阅读
目的研究血栓通注射液联合单唾液酸四己糖神经节苷脂对脑梗死的治疗效果。方法选择2013年1月—2015年12月在新疆维吾尔自治区职业病医院进行诊治的脑梗死患者100例,随机分为两组。对照组静脉滴注血栓通注射液,研究组静脉滴注血栓通注射液及单唾液酸四己糖神经节苷脂,两组均治疗2周。比较两组的治疗效果,血清白介素-6、C反应蛋白水平,NIHSS评分、Barthel指数以及血液流变学变化。结果研究组的有效率为92.00%,明显高于对照组的70.00%,差异有统计学意义(P<0.05)。治疗后两组的血清白介素-6和C反应蛋白水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且研究组血清白介素-6和C反应蛋白水平明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组的NIHSS评分明显降低,Barthel指数明显升高,同组治疗前后比较差异有统计学意义(P<0.05);且研究组明显优于对照组,差异有统计学意义(P<0.05)。治疗后两组的血小板聚集率和血黏稠度均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且研究组血小板聚集率和血黏稠度明显低于对照组,差异有统计学意义(P<0.05)。结论血栓通注射液联合单唾液酸四己糖神经节苷脂具有显著的治疗效果,可以明显改善脑梗死患者的炎症因子水平、神经功能、日常生活能力和血液流变学。
Objective To study the therapeutic effect of Xueshuantong injection combined with monosialotetrahexosyl ganglioside on cerebral infarction. Methods One hundred patients with cerebral infarction who were diagnosed and treated at Occupational Disease Hospital of Xinjiang Uyghur Autonomous Region from January 2013 to December 2015 were randomly divided into two groups. The control group was treated with Xueshuantong Injection, the study group was given Xueshuantong Injection and monosialotetrahexosyl ganglioside, and both groups were treated for 2 weeks. The therapeutic effect, serum interleukin-6, C-reactive protein level, NIHSS score, Barthel index and hemorheology were compared between the two groups. Results The effective rate of the study group was 92.00%, which was significantly higher than that of the control group (70.00%), the difference was statistically significant (P <0.05). Serum levels of interleukin-6 and C-reactive protein in the two groups were significantly decreased after treatment (P <0.05), and the levels of serum interleukin-6 and C-reactive protein in the study group were significantly lower than those in the control group Group, the difference was statistically significant (P <0.05). After treatment, the NIHSS scores of the two groups were significantly decreased, Barthel index was significantly increased, the difference was statistically significant (P <0.05) before and after treatment; and the study group was significantly better than the control group, the difference was statistically significant (P <0.05 ). After treatment, the platelet aggregation rate and blood viscosity of the two groups were significantly decreased, the difference was statistically significant (P <0.05) between the two groups before and after treatment; and the platelet aggregation rate and blood viscosity in the study group were significantly lower than those in the control group Statistical significance (P <0.05). Conclusion Xueshuantong injection combined with monosialotetrahexosyl ganglioside has significant therapeutic effect, which can obviously improve the levels of inflammatory cytokines, neurological function, daily living ability and hemorheology in patients with cerebral infarction.