论文部分内容阅读
目的通过对卵巢早衰(premature ovary failure,POF)相关危险因素及预防知信行(knowledge,attitude and practice,KAP)的调查结果,分析POF的相关危险因素及其预防现状和存在的问题,为预防POF的发病提供参考依据。方法采用病例对照研究方法,选择2014年7月—2015年1月就诊的100例POF患者为病例组,同期200名女性健康体检者为对照组,按年龄、居住地、经济收入情况等进行1∶2配对。两组人群均填写POF相关危险因素调查表及KAP调查问卷。计量资料以x±s表示,采用配对t检验,计数资料采用配对χ2检验。采用条件配对Logistic回归进行多因素分析。P<0.05为差异有统计学意义。结果流产次数(OR=1.806,95%CI为1.016~5.987),吸烟或二手烟(OR=1.794,95%CI为1.364~3.689),经常抑郁、焦虑(OR=3.875,95%CI为1.402~5.899),负性精神刺激经历(OR=3.237,95%CI为1.398~4.324),放疗或化疗史(OR=1.698,95%CI为1.294~3.211),有家族遗传史(OR=1.912,95%CI为1.187~2.798),生存压力(OR=2.119,95%CI为1.309~4.101)均是POF的危险因素(均P<0.05)。“环境污染是POF发病的危险因素”的知晓率最高,为86.00%(258/300);“性交疼痛、性欲淡漠是临床表现之一”的知晓率最低,仅为7.00%(21/300)。结论流产、吸烟、情绪因素及不良生活方式等是POF发生的主要影响因素,因此引导女性建立良性生活方式,提高对POF的预防和治疗意识,减缓POF的发生和发展,提高女性的健康水平非常具有必要性和可行性。
Objective To analyze the related risk factors of POF and its prevention status and existing problems by investigating the related risk factors and KAP of premature ovarian failure (POF). To prevent POF The incidence of providing a reference. Methods A case-control study was conducted. One hundred POF patients treated from July 2014 to January 2015 were selected as the case group and 200 female healthy subjects were selected as the control group according to their age, place of residence and economic income. : 2 pairing. Two groups of people were filled POF-related risk factors questionnaire and KAP questionnaire. Measurement data to x ± s that the use of paired t test, count data using paired χ2 test. Logistic regression was used for multivariate analysis. P <0.05 for the difference was statistically significant. Results The number of miscarriage (OR = 1.806, 95% CI: 1.016-5.987), smoking or secondhand smoke (OR = 1.794, 95% CI: 1.364-3.689) 5.899), history of negative mental stimulation (OR = 3.237, 95% CI 1.398-4.324), history of radiotherapy or chemotherapy (OR = 1.698, 95% CI 1.294-3.211), family history % CI was 1.187-2.798). Survival pressure (OR = 2.119, 95% CI 1.309-4.101) was a risk factor for POF (all P <0.05). “Environmental pollution is the risk factor for the incidence of POF ” the highest awareness rate was 86.00% (258/300); “sexual intercourse pain, apathetic sex is one of the clinical manifestations ” the lowest awareness rate, only 7.00% 21/300). Conclusions Abortion, smoking, emotional factors and unhealthy lifestyles are the main influencing factors of POF. Therefore, guiding women to establish a benign life style, improving their awareness of prevention and treatment of POF, slowing down the occurrence and development of POF, and improving women’s health are very common Has the necessity and feasibility.