双氯芬酸钠(1)是一种高效消炎、解热、镇痛、抗风湿药物。在其多种制备方法[1～4]中,由邻氯苯乙酸(2)和2,6-二氯苯胺(3)合成1较为简便,文献[3,4]报道该路线的收率都在42.5%以下。如在反应时滴加二甲苯并利用二甲苯的馏出除去反应中生成的水,可使1的收率达到50%[5],但仍须采用氮 Diclofenac sodium (1) is a highly effective anti-inflammatory, antipyretic, analgesic and antirheumatic drugs. The synthesis of 1 from o-chlorophenylacetic acid (2) and 2,6-dichloroaniline (3) is simpler in many of its preparation methods [1 ~ 4]. The yield of this route is reported in [3,4] Below 42.5%. For example, when xylene is added dropwise during the reaction and the xylene is distilled off to remove water generated in the reaction, the yield of 1 can reach 50% [5], but nitrogen