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世界卫生组织报道,全球每年约有160万人因肺炎链球菌性疾病死亡(其中约有70~100万5岁以下儿童)。在全球疫苗可预防疾病中,肺炎链球菌疾病已成为导致5岁以下儿童死亡的首要病因。于1940年引进青霉素使得肺炎链球菌疾病的发病率和病死率急剧下降,然而,其过度使用导致青霉素耐药菌出现,多重耐药(MDR)肺炎链球菌的广泛传播已成为一个不容忽视的公共健康问题。根据肺炎链球菌荚膜多糖抗原的差异,大约可鉴别出90余种血清型,致病的血清型虽在年龄和
According to the World Health Organization, about 1.6 million people worldwide die of pneumococcal disease each year (of which about 70 to 1 million children under 5 years of age). Among the global vaccine-preventable diseases, pneumococcal disease has become the leading cause of death in children under five years of age. The introduction of penicillin in 1940 caused a drastic drop in the incidence and mortality of pneumococcal disease. However, its overuse led to the emergence of penicillin-resistant bacteria. The widespread transmission of multi-drug resistant (MDR) Streptococcus pneumoniae has become a public that can not be ignored Health problems. According to the difference of S. pneumoniae capsular polysaccharide antigen, about 90 kinds of serotypes can be identified. Although pathogenic serotypes differ in age and