预防呼吸道的链球菌感染,对于防止风湿热以及风湿性心脏病的发生很为重要。每周注射青霉素120万 U 最为有效,但由于注射部位痛感较重,加以有出现过敏反应的潜在危险,有人乃改青霉素注射为口服应用。但这易促使患者咽部链球菌产生青霉素酶而将青霉素破坏以致往往失败,严重病例,该耐药菌可并发细菌性心内膜炎。因此,有必要寻找其它可以替代的药物,红霉素及磺胺嘧啶等亦可使用。本文报告 Prevention of respiratory tract streptococcal infection, for the prevention of rheumatic fever and rheumatic heart disease is very important. Penicillin 1.2 million weekly injection of U is the most effective, but due to severe pain at the injection site, there is a potential risk of allergic reactions, some people are penicillin injection for oral use. But it is easy to promote the patient’s throat streptococcus produce penicillinase and penicillin often destroyed, in severe cases, the resistant bacteria can be complicated by bacterial endocarditis. Therefore, it is necessary to find other alternative drugs, erythromycin and sulfadiazine can also be used. This report