论文部分内容阅读
目的探讨清金化痰汤联合雾化治疗老年慢性支气管炎的临床效果。方法选取2014年1月—2016年1月本院收治的老年慢性支气管炎患者126例作为调查对象。采用随机数表法将其分为观察组与对照组各63例,其中对照组患者单纯接受常规药物治疗,观察组在对照组基础上内服中药方剂清金化痰汤化裁方内服联合雾化,两组患者共治疗4个疗程,比较两组患者治疗前后中医症候积分、体内炎性相关因子及血液流变学指标改善情况及治疗总有效率。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果治疗后两组患者总积分均显著降低[(18.92±8.13)、(13.59±7.61)分],但观察组患者改善效果更明显,与对照组比较,差异有统计学意义(P<0.05)。治疗后两组患者IL-6及TNF-α活性水平[(231.7±26.9)、(160.5±8.6)pg/ml与(44.9±5.6)、(32.6±9.7)pg/ml]均明显降低,但观察组患者改善效果更显著,差异均有统计学意义(均P<0.05)。观察组治疗后总有效率为93.65%,明显高于对照组的79.37%,差异有统计学意义(χ~2=5.508,P<0.05)。结论清金化痰汤联合方剂雾化吸入治疗老年慢性支气管炎疗效确切,可有效改善患者体内炎性因子及血液流变学指标,治疗总有效率得到显著提高,具有临床应用及推广价值。
Objective To investigate the clinical effect of Qingjin Huatan Decoction combined with atomization on senile chronic bronchitis. Methods From January 2014 to January 2016, 126 elderly patients with chronic bronchitis admitted to our hospital were enrolled in this study. The random number table method was divided into the observation group and the control group of 63 cases, in which the control group of patients received simple conventional drug treatment, the observation group in the control group on the basis of oral administration of traditional Chinese medicine prescription Qingjin Huatan Decoction oral side combined with atomization , Two groups of patients were treated for 4 courses. The TCM symptom score, inflammatory factors and hemorrheological indexes in both groups before and after treatment were compared, and the total effective rate of treatment was compared. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results After treatment, the total score of the two groups was significantly lower (18.92 ± 8.13, 13.59 ± 7.61), but the improvement effect in the observation group was more obvious. Compared with the control group, the difference was statistically significant (P0.05) . The levels of IL-6 and TNF-αin the two groups were significantly lower than those in the control group [(231.7 ± 26.9), (160.5 ± 8.6) pg / ml and (44.9 ± 5.6), (32.6 ± 9.7) pg / ml] The improvement effect of observation group was more significant, the difference was statistically significant (all P <0.05). The total effective rate of the observation group after treatment was 93.65%, which was significantly higher than that of the control group (79.37%), the difference was statistically significant (χ ~ 2 = 5.508, P <0.05). Conclusion Qingjinhuatan Decoction combined with nebulizer inhalation for the treatment of senile chronic bronchitis is effective and can effectively improve the inflammatory cytokines and hemorheology indexes in the patients. The total effective rate has been significantly improved, which has clinical application and promotion value.