论文部分内容阅读
在作者过去的研究工作中曾发现实验性锰中毒时脑细胞的损害与组织中锰含量直接有关,认为锰可能对脑组织有直接毒性作用,或与血中蛋白质结合为有毒化合物而造成脑损害。本文就锰对血清和脑脊液中蛋白质和腺甙脱氨酶(简称AD)的影响进行观察,以图寻找锰中毒性脑病的临床化验指标。实验分为实验组及对照组,各用雄性家兔12只。实验组每只家兔经气管注入二氧化锰粉尘(颗粒为5微米大小)400毫克(以生理盐水1.5毫升配成悬液),对照组则各予气
In the author’s previous work, it was found that the damage of brain cells during experimental manganese poisoning was directly related to the content of manganese in the tissues. It is believed that manganese may have a direct toxic effect on brain tissue or combine with blood proteins to form toxic compounds and cause brain damage . In this paper, the impact of manganese on serum and cerebrospinal fluid protein and adenosine deaminase (AD) were observed in order to find the clinical laboratory indicators of manganese poisoning encephalopathy. The experiment was divided into experimental group and control group, each with 12 male rabbits. Experimental group, each rabbit was injected via tracheal manganese dioxide dust (particle size of 5 microns) 400 mg (1.5 ml saline solution dubbed the suspension), the control group, each to the gas