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研究125例SLH发现,在73例IgG抗心肌磷脂抗体阳性中有8例(11％)自然流产,明显高于阴性病例(P<0.05)。 SLE女性与健康女性比较,受孕率无变化而自然流产率增高。SLE孕妇胎盘较健康孕妇胎盘小而轻,这种改变与SLE疾病的活动性,血小板减少症,低补体血症有关。另外在SLE中,与自然流产有关的自身抗体除抗磷脂抗体外,还有抗淋巴细胞抗体,抗SS·A(R_0)抗体,抗poly(ADP核糖)抗体。其中抗心肌磷脂抗体的测定对预测SLE妊娠中胎儿窘迫或胎儿死亡极有价值。
Study of 125 cases of SLH found that in 73 cases of IgG anti-cardiolipin antibody positive in 8 cases (11%) spontaneous abortion, significantly higher than the negative cases (P <0.05). SLE women compared with healthy women, no change in conception rate and spontaneous abortion increased. SLE placenta of pregnant women than healthy pregnant women placenta small and light, this change and SLE disease activity, thrombocytopenia, hypocomplementemia. In addition, in SLE, autoantibodies associated with spontaneous abortion are anti-phospholipid antibodies, anti-lymphocyte antibodies, anti-SS A (R 0) antibodies and anti-poly ADP ribose antibodies. Anti-cardiolipin antibodies in which the prediction of SLE pregnancy fetal distress or fetal death of great value.