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为探讨视网膜母细胞瘤色素上皮 -脉络膜分期与视神经浸润的关系 ,于光镜下观察 2 97例原发视网膜母细胞瘤摘除眼球的组织病理切片中视网膜色素上皮、玻璃膜和脉络膜的变化及视神经浸润的情况。将视神经浸润分为视神经无浸润 (N0 ) ,筛板前浸润 (N1) ,筛板浸润 (N2 ) ,筛板后浸润 (N3) 4期。结果显示 ,N0占 6 1.95 % ,N1占 2 1.2 1% ,N2占 10 .78% ,N3占 6 .0 6 %。在视神经浸润度为 N0～N2时 ,色素上皮 -脉络膜分期也处于 期和 期 ,此时视神经和球壁的局部屏障均尚未破坏 ,肿瘤细胞转移率仅为 0 .73% ,而视神经浸润破坏筛板屏障时 (N3) ,色素上皮 -脉络膜分期也达到 期 ,此时肿瘤细胞转移率高达 11.76 %。因此 ,随着视神经浸润度的加深 ,色素上皮 -脉络膜分期的程度也加重 ,肿瘤细胞发生转移的可能性也增大
To investigate the relationship between retinal pigment epithelium-choroidal staging and optic nerve infiltration in retinoblastoma, the changes of retinal pigment epithelium, vitreous membrane and choroid in optic nerve tissue were observed under light microscope in 2 97 cases of primary retinoblastoma. Infiltration of the situation. The optic nerve infiltration was divided into no optic nerve infiltration (N0), pre-sieve infiltration (N1), infiltration of sieve (N2), sieve infiltration (N3) 4. The results showed that N0 accounted for 6 1.95%, N1 accounted for 2 1.2 1%, N2 accounted for 10.78% and N3 accounted for 6. 06%. In the optic nerve infiltration degree of N0 ~ N2, the pigment epithelium - choroidal staging is also in the stage and period, when the local barrier of the optic nerve and the ball wall have not yet been destroyed, the rate of tumor cell metastasis was only 0.73%, while the optic nerve invasion rupture sieve Plate barrier (N3), pigment epithelium - choroidal staging is also reached, when tumor cell metastasis rate as high as 11.76%. Therefore, with the deepening degree of optic nerve infiltration, the degree of pigment epithelium - choroidal staging also increased, the possibility of tumor cell metastasis also increased