全细胞百日咳疫苗 ( Pw)免疫接种在有效预防婴儿百日咳的同时 ,也引起局部、全身及神经元副反应 ,包括儿童发热和惊厥。作者建立了一种新型小鼠模型 ,并在此模型中研究了 Pw接种后引起神经元反应的机理。　　实验 1 :选取 8～ 1 0周龄 BAL B/c雌鼠 ,分别皮下注射 0 .2 ml Pw、 Whole-cell pertussis vaccine (Pw) immunization in the prevention of infant whooping cough, but also cause local, systemic and neuronal side effects, including fever and convulsions in children. The authors established a novel mouse model and studied the mechanism of neuronal response after Pw inoculation in this model. Experiment 1: Eight to ten-week-old BALB / c female mice were selected and subcutaneously injected with 0.2 ml Pw,