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目的 :分析肾性贫血对慢性肾脏病(CKD)患者肾功能进展的影响。方法 :回顾性分析CKDⅢ、Ⅳ、Ⅴ期患者血红蛋白变异度与内生肌酐清除率(Ccr)的相关性,对不同血红蛋白波动度组别间肾功能进展对比。结果 :48例CKD中血红蛋白波动组患者的Ccr增长均高于血红蛋白稳定组,差异具有统计学意义。结论 :血红蛋白的波动加重患者的肾功能进展。
Objective: To analyze the effect of renal anemia on the progression of renal function in patients with chronic kidney disease (CKD). Methods: The correlation between hemoglobin variation and endogenous creatinine clearance (Ccr) in patients with stage Ⅲ, Ⅳ and Ⅴ CKD was retrospectively analyzed. The progression of renal function in different hemoglobin fluctuation groups was compared. Results: The Ccr increase of hemoglobin fluctuation group was higher than that of hemoglobin group in 48 CKD patients, the difference was statistically significant. Conclusion: Hemoglobin fluctuation aggravates renal function in patients.