The grisliness after-effects can be induced by explosion accident with the collapsing of the structures, the demolishing of the equipments and the casualty of the human beings. Isolation belt constructed between the blast point and the construction is one of the useful design schemes for blast resistance. The nonlinear procedure ANSYS/LSDYNA970 is used to simulate the contact detonation and the isolation belt of blast resistance filled with the air or water respectively. The results indicate that the maximal damage can be caused by the contact detonation, and the isolation belt of blast resistent filled with water can reduce the damage greatly. The grisliness after-effects can be induced by explosion accident with the collapsing of the structures, the demolishing of the equipments and the casualty of the human beings. Isolation belt constructed between the blast point and the construction is one of the useful design schemes for blast The nonlinear procedure ANSYS / LSDYNA970 is used to simulate the contact detonation and the isolation belt of blast resistance filled with the air or water respectively. The results that that maximal damage can be caused by the contact detonation, and the isolation belt of blast resistent filled with water can reduce the damage greatly.