以干扰素为基础的治疗是目前丙型肝炎病毒感染者唯一有效的治疗手段,但干扰素疗效受病毒因素、宿主免疫状态和干扰素剂型等影响,且干扰素价格昂贵,疗程长,又有一定的不良反应。因此,对丙型肝炎患者治疗前或早期治疗过程中进行干扰素疗效的预测,将有助于对临床病例进行合理的干扰素治疗。本文综述了丙型肝炎病毒的基因型、治疗前血清中病毒载量水平、病毒变异率,以及治疗过程中病毒动力学变化等病毒自身因素和干扰素疗效预测的关系。 Interferon-based treatment is currently the only effective treatment for hepatitis C virus infection, but interferon efficacy is affected by viral factors, host immune status and interferon dosage forms, and interferon is expensive, long course of treatment, there are Certain adverse reactions. Therefore, predicting the efficacy of interferon in the treatment of hepatitis C patients before or during treatment will be helpful for rational interferon treatment of clinical cases. This article reviews the relationship between the HCV genotypes, the serum levels of viral load in pre-treatment serums, the virus mutation rates, and the virus self-factors such as changes in virus dynamics during treatment, and the prediction of efficacy of interferon.