本文采用放射配基结合法,观察了实验性哮喘豚鼠肺组织β-肾上腺素能受体的变化,并与正常动物作了比较。结果表明,哮喘豚鼠肺组织的β-受体结合~3H-DHA的最大结合量(BmAX)比对照组者低38%(P<0.01)。首次观察到随哮喘发作次数的增多,豚鼠肺组织β-受体的减少趋于明显;电针刺激可使哮喘豚鼠肺组织的β-受体数量恢复至对照动物水平。电针刺激对正常动物的β-受体数量未见有影响。 In this study, the changes of β-adrenergic receptors in lung tissue of experimental asthmatic guinea pigs were observed using radioligand binding assays and compared with normal animals. The results showed that the maximum binding amount (BmAX) of β-receptor binding to 3H-DHA in lung tissue of asthmatic guinea pigs was 38% lower than that in the control group (P<0.01). For the first time, with the increase of the number of asthma attack, the decrease of β-receptor in lung tissue of guinea pigs tends to be obvious; electro-acupuncture stimulation can restore the β-receptor quantity of lung tissue of asthmatic guinea pigs to the level of control animals. Electroacupuncture stimulation had no effect on the number of β-receptors in normal animals.