热疗通过提高免疫效应细胞活性、诱导免疫效应细胞再分布、影响细胞因子表达、诱导热休克蛋白表达上调等作用调节机体的免疫功能,抑制肿瘤生长和转移。热疗与细胞因子、树突状细胞、肿瘤疫苗、基因治疗等免疫疗法的联合应用,在体外和小鼠肿瘤模型中显示了一定的有效性,但目前还处于实验室研究阶段,有待于进一步完善。 Hyperthermia regulates the body’s immune function by increasing the immune effector cell activity, inducing redistribution of immune effector cells, affecting cytokine expression, and inducing up-regulation of heat shock protein, and inhibits tumor growth and metastasis. The combination of hyperthermia and immunotherapy such as cytokines, dendritic cells, tumor vaccines, and gene therapy has shown some effectiveness in vitro and in mouse tumor models, but it is still in the laboratory research stage and needs to be further studied. perfect.