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目的探讨E-钙黏蛋白及三阴性表达与乳腺癌临床、病理特征的关系。方法浸润性乳腺癌患者280例,采用免疫组织化学法检测雌激素受体、孕激素受体、人类表皮生长因子受体-2及E-钙黏蛋白表达情况,分析E-钙黏蛋白表达及三阴性与患者临床病理特点间关系。结果 280例患者中三阴性乳腺癌患者32例(TNBC组),非三阴性乳腺癌患者248例(非TNBC组);TNBC组肿瘤直径>2cm、组织病理分级Ⅱ和Ⅲ级、淋巴管有浸润比例及E-钙黏蛋白表达阴性率(75.0%、68.7%、46.9%、71.9%)高于非TNBC组(51.2%、46.0%、21.0%、33.5%),差异有统计学意义(P<0.05);淋巴结有转移者E-钙黏蛋白表达阴性率(46.1%)高于淋巴结无转移者(29.5%),差异有统计学意义(P<0.05)。结论 E-钙黏蛋白及三阴性表达与乳腺癌多种临床病理特点有相关性。
Objective To investigate the relationship between E-cadherin and triple negative expression and clinical and pathological features of breast cancer. Methods 280 cases of invasive breast cancer patients, immunohistochemical detection of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 and E-cadherin expression, E-cadherin expression and Relationship between triple negative and clinicopathological features of patients. Results Thirty-two patients (TNBC group) and 248 non-TNBC patients (non-TNBC group) in 280 patients were TNBC group. TNBC group had tumor diameter> 2cm, histological grade Ⅱ and Ⅲ, (51.0%, 68.7%, 46.9%, 71.9%) were significantly higher than those in non-TNBC group (51.2%, 46.0%, 21.0%, 33.5%), the difference was statistically significant (P < 0.05). The negative expression rate of E-cadherin in lymph node metastasis (46.1%) was higher than that in non-lymph node metastasis (29.5%), the difference was statistically significant (P <0.05). Conclusions E-cadherin and triple negative expression are closely related to various clinicopathological features of breast cancer.