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选用１月龄ＩＣＲ品系小鼠，随机分成４组，分别饮用１ｍｇ／Ｌ（低氟组）、５ｍｇ／Ｌ（中氟组）、１０ｍｇ／Ｌ（高氟组）的氟化钠溶液和蒸馏水（对照组），８周后用开场行为和Ｙ－迷宫模型观察慢性氟中毒对小鼠学习记忆行为的影响；１０周后检测氟中毒对小鼠运动耐力的影响。结果表明：（１）中氟组和高氟组小鼠后腿站立次数和移动格数均少于对照组和低氟组，且以高氟组的变化最大；（２）随着氟浓度的增大，小鼠的学习能力明显下降（Ｐ＜０．０５，高氟组与对照组相比），而对记忆保持力却无显著影响；（３）运动耐力测定时，在水中淹死的时间中氟组和高氟组比低氟组低得多（Ｐ＜０．０５和Ｐ＜０．０１）。结果提示，慢性氟中毒对小鼠的一些开场行为和学习能力以及运动耐力有显著的影响
The 1-month-old ICR mice were randomly divided into 4 groups and were respectively treated with 1 mg / L (low fluoride group), 5 mg / L (medium fluoride group), 10 mg / L (high fluoride group) sodium fluoride solution and distilled water Control group). After 8 weeks, the opening behavior and Y-maze model were used to observe the effects of chronic fluorosis on learning and memory behaviors of mice. After 10 weeks, the effects of fluorosis on exercise tolerance of mice were observed. The results showed that: (1) The number of hind legs and the number of moving hind legs in the medium and high fluoride groups were less than those in the control group and the low fluoride group, with the highest changes in the high fluoride group; (2) (P <0.05, high-fluoride group compared with the control group), but had no significant effect on the memory retention; (3) during exercise endurance test, the water-drowning Fluorine group and high fluoride group were much lower than low fluoride group in time (P <0.05 and P <0.01). The results suggest that chronic fluorosis has a significant impact on some mouse opening behavior and learning ability and exercise tolerance