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目的通过对现有流行病学资料的总结,分析牛奶及其制品消费与结肠癌的发生是否关联,为寻找预防对策提供依据。方法收集牛奶及其制品与结肠癌关系的病例对照研究进行meta分析。结果有11篇病例对照研究被纳入meta分析,固定效应模型分析显示牛奶、奶制品、奶酪的消费与结肠癌发病的总比值比(OR)及95%可信区间(CI)分别为0.87(0.68～1.12)、0.96(0.75～1.23)、0.98(0.85～1.14)。结论通过meta分析提示牛奶及其制品可能与结肠癌的发生无关联。
Objective To summarize the existing epidemiological data, and to analyze whether the consumption of milk and its products is related to the occurrence of colon cancer, so as to provide a basis for the prevention measures. Methods A meta-analysis of case-control studies on the relationship between milk and its products and colon cancer was performed. Results Eleven case-control studies were included in the meta-analysis. The fixed-effects model analysis showed that the odds ratio (OR) and 95% confidence interval (CI) between milk consumption, dairy products, cheese consumption and colon cancer incidence were 0.87 (0.68 ~ 1.12), 0.96 (0.75-1.23), 0.98 (0.85-1.14). Conclusions Meta-analysis suggests that milk and its products may not be associated with the development of colon cancer.