本文报告２例巨指畸形，其患儿父母均体健，非近亲结婚。病理组织学检查示巨指表皮萎缩，真皮胶原纤维透明变性，皮下脂肪组织增生。例１其母在妊娠第１－第１６周有Ｘ线接触史，对母体无害剂量的照射可能危及胎儿。本病应与婴儿指（趾）纤维瘤病、多发性神经纤维瘤病、血管瘤等鉴别。治疗方面目前采用截骨或缩短手指术、神经主干切除术 This article reports 2 cases of giant deformities, their parents are healthy, non-relatives get married. Histopathological examination revealed a large epidermis atrophy, dermal collagen fibers transparent degeneration, subcutaneous adipose tissue hyperplasia. Example 1 The mother had a history of X-ray exposure during the first 16 weeks of gestation and exposure to a noninfectious maternal dose could endanger the fetus. The disease should be with the baby finger (toe) fibromatosis, multiple neurofibromatosis, hemangioma and other identification. The current treatment of osteotomy or shortening the finger surgery, nerve trunk resection