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目的：探讨普罗布考对脑梗死合并认知功能障碍患者β淀粉样蛋白1-40（Aβl-40）和基质金属蛋白酶-9（MMP-9）的影响。方法选择2012年12月～2014年10月于唐山市人民医院诊治的脑梗死合并认知功能障碍患者138例，男性81例，女性57例，年龄52～74岁。随机分为两组，对照组和观察组，各69例。对照组采用阿托伐他汀治疗，观察组采用阿托伐他汀联合普罗布考治疗，疗程6个月。比较两组患者治疗前后的神经功能状况、认知功能状况、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、Aβl-40和MMP-9改变情况。结果治疗6个月后，两组患者较治疗前NIHSS评分均显著降低，MMSE评分、MoCA评分均显著增加，差异有统计学意义（P均＜0.05）。观察组治疗后NIHSS评分明显低于对照组，MMSE评分、MoCA评分均明显高于对照组，差异均具有统计学意义（P均＜0.05）。治疗后，两组患者TC、TG、LDL-C均显著降低，HDL-C均显著增加，差异有统计学意义（P均＜0.05）。观察组治疗后TC、TG、LDL-C均明显低于对照组，HDL-C明显高于对照组，差异均具有统计学意义（P均＜0.05）。治疗6个月后，两组患者Aβl-40、MMP-9均显著降低，观察组患者治疗后Aβl-40、MMP-9均明显低于对照组，数值为[（130.27±16.93）pg/ml vs.（154.17±20.41）pg/ml]，[（196.04±43.28）mg/Lvs.（256.37±51.23）mg/L]，差异均具有统计学意义（P均＜0.05）。观察组患者不良反应发生率与对照组相比，差异无统计学意义（P＞0.05）。结论普罗布考可明显改善脑梗死合并认知功能障碍患者的神经功能状况和认知功能状况，调节血脂，能降低Aβl-40和MMP-9水平，具有较高的安全性。“,”Objective To investigate the influence of probucol on β-amyloid protein 1-40 (Aβl-40) and matrix metalloproteinase-9 (MMP-9) in patients with cerebral infarction complicated by cognitive dysfunction.Methods The patients (n=138, male 81, female 57 and aged from 52 to 74) were chosen from Dec. 2012 to Oct. 2014, and randomly divided into control group and observation group (eachn=69). The control group was treated with atorvastatin, and observation group, with atorvastatin combining probucol for 6 m. The status of neurological function and cognitive function, and changes of total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), Aβl-40 and MMP-9 were compared in 2 groups before and after treatment. Results After treatment for 6 m, NIHSS scores decreased significantly, and MMSE scores and MoCA scores increased significantly in 2 groups (allP<0.05). NIHSS scores were significantly lower, and MMSE scores and MoCA scores were significantly higher in observation group than those in control group after treatment (allP<0.05). The levels of TC, TG and LDL-C decreased significantly and level of HDL-C increased significantly in 2 groups after treatment (all P<0.05). The levels of TC, TG and LDL-C were significantly lower, and level of HDL-C was significantly higher in observation group than those in control group after treatment (allP<0.05). After treatment for 6 m, the levels of Aβl-40 and MMP-9 decreased significantly in 2 groups. The levels of Aβl-40 [(130.27±16.93) pg/mLvs. (154.17±20.41) pg/mL] and MMP-9 [(196.04±43.28) mg/Lvs. (256.37±51.23) mg/L] were significantly lower than those in control group (allP0.05). Conclusion Probucol can significantly improve the status of neurological function and cognitive function, regulate blood fat and reduce the levels of Aβl-40 and MMP-9 with higher safety.