目的探讨苹果皮提取物(apple peel extract,APE)对胰岛素耐性有关的肥胖病以及由高脂肪食物引起的2型糖尿病的作用。方法以8周龄期的C57BL/6小鼠为实验模型,分为饲喂高脂食物组(HF组)、饲喂低脂食物组(LF组)、HF+APE组、LF+APE组,对比饲小鼠的体重、血糖、胰岛素和甘油三酯水平。结果 APE明显改善了HF小鼠对糖的耐受性和胰岛素的敏感性,口服APE的HF小鼠炎症早期细胞因子水平和脂肪组织中氧化水平显著降低。结论 APE能部分提高C57BL/6小鼠抗感染和抗氧化的能力,也能有助于2型糖尿病的治疗。 Objective To investigate the effects of apple peel extract (APE) on insulin resistance-related obesity and type 2 diabetes caused by high fat diet. Methods Eight-week old C57BL / 6 mice were divided into four groups: HF-fed group, LF-fed group, HF + APE group, LF + APE group, The weight, blood glucose, insulin and triglyceride levels of the mice were compared. Results APE significantly improved glucose tolerance and insulin sensitivity in HF mice. The level of inflammatory cytokines and the level of oxidation of adipose tissue in HF-treated APE mice were significantly decreased. Conclusion APE can partially improve the anti-infective and anti-oxidative ability of C57BL / 6 mice and also contribute to the treatment of type 2 diabetes mellitus.