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过去在肿瘤放射生物学的研究工作中,通常都是以离体单层贴壁生长的细胞作为体外实验的模型,由于这种离体培养的细胞与体内实体肿瘤存在一定的差异,以致离体实验的结果,往往不能很好地应用于体内肿瘤。1971年Sutherland等首先使用中国仓鼠V79肺细胞培养了具有三维结构的多细胞球
In the past, studies on tumor radiobiology have generally used in vitro monolayer-attached cells as a model for in vitro experiments. This in vitro cultured cell has a certain difference from solid tumors in vivo, resulting in ex vivo The results of the experiment often do not apply well to tumors in vivo. In 1971 Sutherland et al. first used a Chinese hamster V79 lung cell to culture a multicellular sphere with a three-dimensional structure.