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测定实验性阴虚证及通脉降脂灵预防治疗小鼠脾脏微量元素锌、铜含量 ,探讨通脉降脂灵对阴虚证所致小鼠免疫功能下降的预防变化作用。方法 实验用二级昆明系小鼠 ,随机分为正常对照组、阴虚证模型组、通脉降脂灵预防组。测定各组微量元素锌、铜含量及脾脏重量变化。结果 阴虚组与对照组比较 ,锌、铜含量均显著降低 (P<0 .0 1)。药物组与阴虚组比较 ,其铜含量显著升高 (P<0 .0 1) ,锌也有显著升高 (P<0 .0 5 )。药物组同对照组比较 ,锌铜含量均无差异 (P>0 .0 5 )。结论 通脉降脂灵具有调节阴虚小鼠脾脏中的锌、铜含量 ,能增强机体免疫力的作用 ,对阴虚证所致机体免疫功能下降 ,有一定的防治作用。
The contents of zinc and copper in the spleen of mice treated with experimental Yin Deficiency Syndrome and Tong Mai Jiangzhiling were measured, and the effects of Tongmai Jiangzhiling on the immune function decline induced by yin deficiency syndrome were investigated. Methods Two Kunming mice were randomly divided into normal control group, Yin deficiency syndrome model group and Tongmai Jiangzhiling prevention group. The contents of trace elements zinc and copper and spleen weight were determined. Results Compared with the control group, Yin deficiency group had significantly lower zinc and copper contents (P<0.01). Compared with Yin deficiency group, the copper content of the drug group was significantly increased (P<0.01) and zinc was also significantly increased (P<0.05). There was no difference in zinc and copper contents between the drug group and the control group (P>0.05). Conclusion Tongmai Jiangzhiling can regulate the contents of zinc and copper in the spleen of mice with yin deficiency. It can enhance the immune function of the body and reduce the immune function caused by yin deficiency syndrome. It has certain preventive and therapeutic effects.