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目的:检测CXCL12及CXCR4在口腔扁平苔藓中(OLP)的表达及分布。方法:将31例OLP黏膜标本按病损类型分型、分级,免疫组化检测CXCL12及CXCR4的表达,测量CXCL12及CXCR4的累积光密度值(IOD)。结果:1OLP组织中可以检测到CXCL12及CXCR4表达,其表达向表层扩展且逐渐增强。2依临床分型分组,网纹组、糜烂组与对照组差异均具有统计学意义(P<0.05);网纹型与糜烂型相比,CXCL12的IOD降低,CXCR4的IOD升高,网纹组与糜烂组差异无统计学意义(P>0.05)。3CXCL12及CXCR4依临床分级分组,5组之间的差异没有统计学意义(P>0.05),且临床分级与IOD无明显相关性(P>0.05)。4CXCL12的IOD与CXCR4的IOD呈正相关。结论:CXCL12及CXCR4在OLP中分布及表达的差异,提示CXCL12/CXCR4轴在OLP的发生发展中可能起到一定作用。
Objective: To detect the expression and distribution of CXCL12 and CXCR4 in oral lichen planus (OLP). Methods: The expression of CXCL12 and CXCR4 in 31 cases of OLP mucosa were classified according to the type of lesion. The expressions of CXCL12 and CXCR4 were detected by immunohistochemistry. The cumulative optical density (IOD) of CXCL12 and CXCR4 were measured. Results: The expressions of CXCL12 and CXCR4 were detected in 1OLP tissues. (P <0.05). Compared with the erosive type, the IOD of CXCL12 was decreased and the IOD of CXCR4 was increased. The number of reticulocytes No significant difference between group and erosion group (P> 0.05). 3CXCL12 and CXCR4 were grouped according to clinical classification. There was no significant difference between the 5 groups (P> 0.05). There was no significant correlation between clinical grade and IOD (P> 0.05). The IOD of 4CXCL12 was positively correlated with IOD of CXCR4. Conclusion: The differences in the distribution and expression of CXCL12 and CXCR4 in OLP suggest that CXCL12 / CXCR4 axis may play a role in the occurrence and development of OLP.