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采用银染聚合酶链反应—单链构象多态分析方法对口腔粘膜鳞状细胞癌发生、发展过程中ｐ５３基因５～８号外显子的突变情况及其在这４个外显子中的分布进行了研究。结果发现，在口腔粘膜癌前损害组织中，主要以５、７号外显子异常为主，而无淋巴结转移和有淋巴结转移的粘膜鳞状细胞癌组则分别由６、７号外显子占多数。是否意味着７号外显子异常的口腔粘膜癌前损害更易恶变，７号外显子异常的口腔粘膜鳞状细胞癌更易发生淋巴结转移，值得进一步探讨。
The mutation of p53 gene exon 5-8 and its distribution in the four exons of oral mucosa squamous cell carcinoma were detected by silver staining polymerase chain reaction-single strand conformation polymorphism Were studied. The results showed that in the premalignant lesions of oral mucosa, the main exon 5 and exon 7 were abnormal, but no lymph node metastasis and lymph node metastasis of mucosal squamous cell carcinoma were respectively 6,7 exons accounted for the majority . Does it mean that Exon 7 abnormal oral mucosa precancerous lesions more easily malignant, Exon 7 abnormal oral mucosa squamous cell carcinoma more prone to lymph node metastasis, it is worth further study.